Antidote Chart

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Antidote Chart

The Indiana Poison Center is pleased to provide our Antidote Stocking List. It has been shown that many hospitals do not maintain adequate types and quantities of antidotes to manage anticipated poisonings and overdoses. Our listing of common antidotes also includes an Acuity rating as to the urgency of availability and a stocking level that takes into account whether or not a poison is anticipated to be in a mass casualty incident. The stocking levels should be sufficient to treat one 70 kg patient for one day, except in the cases of antidotes needed for mass casualty incident, where the stocking level is sufficient to treat 5 patients.  Mass casualty incidents require greater quantities of antidotes. If your emergency planning indicates a potential need for increased numbers of antidotes to meet a specific need, please call Indiana Poison Center at 1-800-222-1222 for an individualized consult.

Antidote Available Forms Indications Acuity Dose (Load/Maintenance) Stocking Level1
N-acetylcysteine
(Mucomyst®)
20% x 10, 30, & 100 ml Acetaminophen 3 PO: 140 mg/kg \ 70 mg/kg q 4 hr X 17 100 gm
N-acetylcysteine
(Acetadote®)
20% x 30 ml 3 IV: 150 mg/kg over 60 min \ 12.5 mg/kg/hr x 4 hr then 6.25 mg/kg/hr over 16 hrs 30 gm
(5 vials)
Atropine Sulfate Injection 1 mg/ml x 1 ml 0.4 mg/ml x 20 ml Cholinesterase Inhibitors 1 1-5 mg/dose 100 mg
Digoxin Immune Fab (Digibind®, DigiFab®) 40 mg/vial Digoxin, Digitoxin 2 Individualized 20 vials
Ethanol 95% x 1 ml & 30 ml 10% in D5W x 1 L Methanol, Ethylene Glycol 2 0.6 gm/kg \ 110 mg/kg/hr 42 gm (45 ml) 3 x 1 liter
Fat Emulsion, Intravenous (Intralipid®) 20% x 500 ml Local anesthetics Cardioactive drugs 2 1.5 ml/kg load, may repeat 0.25 ml/kg/min x 60 min 3 x 500 ml
Flumazenil (Romazicon®) 0.1 mg/ml x 5 ml & 10 ml Benzodiazepines 4 0.3 mg: max: 3 mg 10 mg
Fomepizole (Antizol®) 1 gm/ml x 1.5ml Methanol, Ethylene glycol 2 15 mg/kg \ 10mg/kg q 12hr x 4, then 15 mg/kg q 12hr 1 vial (load only) 4 vials (full course)
Glucagon for Injection 1 mg/ml x 1 ml & 10 ml Calcium & Beta Blockers 2 10 mg \ 1-5 mg/hr 130 mg
Hydoxocobalamin (Cyanokit®) 5 gm/vial kit Cyanide 1 5 gm IV, may repeat x 1 5 kits
Insulin, Regular 100 U/ml x 10 ml Calcium & Beta Blockers 2 1 U/Kg load, then 0.5 – 1.0 U/kg/hr (max 10 U/kg/hr) 17 vials
Methylene Blue 10 mg/ml x 10 ml Methemoglobinemia 2 1-2 mg/kg 140 mg
Naloxone (Narcan®) 1 mg/ml x 2 ml & 10 ml Opioids 2 2 mg, up to 10 mg 10 mg
Octreotide (Sandostatin®) 0.1 mg/ml Sulfonylureas 2 Adult: 50-100 mcg
Child: 25-50 mcg
0.3 mg
Physostigmine (Antilirium®) 1 mg/ml x 2 ml Anticholinergics 4 2 mg 4 mg
Pyridoxine IV 100 mg/ml x 10 ml INH, Theophylline 2 mg for mg or 5 gm 10 gm
Pralidoxime (2-Pam, Protopam®) 50 mg/ml x 20 ml Cholinesterase Inhibitors 1 1 gm 5 gm
Sodium Nitrite Injection / Sodium Thiosulfate Injection (Nithiodote®) 30 mg/ml x 10 ml
250 mg/ml x 50 ml
Cyanide, Hydrogen sulfide 1 1-1.5 kits 5 kits
Antivenin          
Crotalidae Polyvalent Immune Fab (Ovine) (CroFab®) 10 ml vials North American Crotalids 3 4-6 vials to initial control, then 3 2 vials q 6 hr x 3 12 vials
Antivenin (Lactrodectus mactans) 2.5 ml vials Black Widow Spiders 4 1-2 vials 2 vials
Chelating Agents          
Deferoxamine (Desferal®) 100 mg/ml x 5 ml Iron 2 15 mg/kg/hr x 4 hr 4.2 gm
Dimercaprol (BAL in Oil®) 100 mg/ml x 3 ml Lead, Arsenic, Mercury 3 3-5 mg/kg q 4 hr 2.1 gm
Edetate Calcium Disodium 200 mg/ml x 5 ml Lead 3 Adult: 50-75 mg/kg/d x 5d
Child: 1-1.5 gm/m2/d x 5d
5.25 gm
Succimer (DMSA, Chemet®) 100 mg capsules Lead, Arsenic, Mercury 3 10 mg/kg TID x 5d, then 10 mg/kg BID x 14d 2.1 gm
Acuity Levels Description Stocking Level1
1 Potentially life-saving, immediate access needed, multiple victims possible Sufficient to treat five (5) 70 kg victims
2 Potentially life-saving, immediate access needed, usually single victims Sufficient to treat one (1) 70 kg victim
3 Emergency, access needed within 4 hours Sufficient to treat one (1) 70 kg victim
4 Not essential, alternative therapies exist Sufficient to treat one (1) 70 kg victim

1 If dosing regimen is more than 1 day, only first day's amount is used as the stocking level